Dunlop Lab @ Unity Health Toronto University of Toronto

Publications

2024

Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.
Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.
Sapolnach Prompiengchai, Katharine Dunlop
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  ·  01 Jul 2024  ·  pubmed:38951585
Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.
Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.
Natalie C W Ho, Richard A I Bethlehem, Jakob Seidlitz, Nikita Nogovitsyn, Paul Metzak, …, Benicio N Frey, Kate L Harkness, Jean Addington, Sidney H Kennedy, Katharine Dunlop
Biological psychiatry. Cognitive neuroscience and neuroimaging  ·  26 Apr 2024  ·  pubmed:38679324
An empirical analysis of structural neuroimaging profiles in a staging model of depression.
An empirical analysis of structural neuroimaging profiles in a staging model of depression.
Nikita Nogovitsyn, Pedro Ballester, Mike Lasby, Katharine Dunlop, Amanda K Ceniti, …, Jean Addington, Kate L Harkness, Susan Rotzinger, Sidney H Kennedy, Benicio N Frey
Journal of affective disorders  ·  28 Jan 2024  ·  pubmed:38290583
Dimensional and Categorical Solutions to Parsing Depression Heterogeneity in a Large Single-Site Sample.
Dimensional and Categorical Solutions to Parsing Depression Heterogeneity in a Large Single-Site Sample.
Katharine Dunlop, Logan Grosenick, Jonathan Downar, Fidel Vila-Rodriguez, Faith M Gunning, Zafiris J Daskalakis, Daniel M Blumberger, Conor Liston
Biological psychiatry  ·  26 Jan 2024  ·  pubmed:38280408

2023

Establishing the Clinical Potential of Brain Aging in Depression: Implications for Suicidality and Antidepressant Response.
Establishing the Clinical Potential of Brain Aging in Depression: Implications for Suicidality and Antidepressant Response.
Natalie C W Ho, Katharine Dunlop
Biological psychiatry. Cognitive neuroscience and neuroimaging  ·  01 Apr 2023  ·  pubmed:37028903
Gray matter volume drives the brain age gap in schizophrenia: a SHAP study.
Gray matter volume drives the brain age gap in schizophrenia: a SHAP study.
Pedro L Ballester, Jee Su Suh, Natalie C W Ho, Liangbing Liang, Stefanie Hassel, …, Sidney H Kennedy, James P Reilly, Lena Palaniyappan, Katharine Dunlop, Benicio N Frey
Schizophrenia (Heidelberg, Germany)  ·  09 Jan 2023  ·  pubmed:36624107

2022

Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression.
Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression.
Aleksandr Talishinsky, Jonathan Downar, Petra E Vértes, Jakob Seidlitz, Katharine Dunlop, …, Andrew McIntosh, Fidel Vila-Rodriguez, Zafiris J Daskalakis, Daniel M Blumberger, Conor Liston
Nature communications  ·  28 Sep 2022  ·  pubmed:36171190
Cardiovascular biomarkers of response to accelerated low frequency repetitive transcranial magnetic stimulation in major depression.
Cardiovascular biomarkers of response to accelerated low frequency repetitive transcranial magnetic stimulation in major depression.
Jack Z Sheen, Jean-Philippe Miron, Farrokh Mansouri, Katharine Dunlop, Thomas Russell, …, Helena Voetterl, Zafiris J Daskalakis, John D Griffiths, Daniel M Blumberger, Jonathan Downar
Journal of affective disorders  ·  31 Aug 2022  ·  pubmed:36055538
Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review.
Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review.
Sarah Kuburi, Anne-Marie Di Passa, Vanessa K Tassone, Raesham Mahmood, Aleksandra Lalovic, Karim S Ladha, Katharine Dunlop, Sakina Rizvi, Ilya Demchenko, Venkat Bhat
Chronic stress (Thousand Oaks, Calif.)  ·  02 Aug 2022  ·  pubmed:35936944
Comparison of Functional and Structural Neural Network Features in Older Adults With Depression With vs Without Apathy and Association With Response to Escitalopram: Secondary Analysis of a Nonrandomized Clinical Trial.
Comparison of Functional and Structural Neural Network Features in Older Adults With Depression With vs Without Apathy and Association With Response to Escitalopram: Secondary Analysis of a Nonrandomized Clinical Trial.
Lauren E Oberlin, Lindsay W Victoria, Irena Ilieva, Katharine Dunlop, Matthew J Hoptman, Jimmy Avari, George S Alexopoulos, Faith M Gunning
JAMA network open  ·  01 Jul 2022  ·  pubmed:35895056
Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review.
Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review.
Ilya Demchenko, Vanessa K Tassone, Sidney H Kennedy, Katharine Dunlop, Venkat Bhat
Frontiers in psychiatry  ·  26 May 2022  ·  pubmed:35722550

2021

Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults.
Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults.
Abhishek Jaywant, Katharine Dunlop, Lindsay W Victoria, Lauren Oberlin, Charles J Lynch, …, Conor Liston, Michael W O’Dell, George S Alexopoulos, Roy H Perlis, Faith M Gunning
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry  ·  29 Jul 2021  ·  pubmed:34412936
A pilot trial of repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex in anorexia nervosa: resting fMRI correlates of response.
A pilot trial of repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex in anorexia nervosa: resting fMRI correlates of response.
D Blake Woodside, Katharine Dunlop, Charlene Sathi, Eileen Lam, Brigitte McDonald, Jonathan Downar
Journal of eating disorders  ·  17 Apr 2021  ·  pubmed:33865456
Accelerated brain aging predicts impulsivity and symptom severity in depression.
Accelerated brain aging predicts impulsivity and symptom severity in depression.
Katharine Dunlop, Lindsay W Victoria, Jonathan Downar, Faith M Gunning, Conor Liston
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  ·  25 Jan 2021  ·  pubmed:33495545

2020

Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression CAN-BIND-1 Report.
Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report.
Katharine Dunlop, Sakina J Rizvi, Sidney H Kennedy, Stefanie Hassel, Stephen C Strother, …, Claudio N Soares, Rudolf Uher, Gustavo Turecki, Glenda M MacQueen, Jonathan Downar
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  ·  01 Jul 2020  ·  pubmed:32349119
Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.
Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.
Nili Solomonov, Lindsay W Victoria, Katharine Dunlop, Matteo Respino, Matthew J Hoptman, …, Lauren Oberlin, Conor Liston, Patricia A Areán, Faith M Gunning, George S Alexopoulos
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry  ·  18 Apr 2020  ·  pubmed:32376080

2019

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial.
Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial.
Katharine Dunlop, Jack Sheen, Laura Schulze, Peter Fettes, Farrokh Mansouri, …, Zafiris J Daskalakis, Sidney H Kennedy, Peter Giacobbe, Blake Woodside, Jonathan Downar
Brain stimulation  ·  31 Oct 2019  ·  pubmed:31711880
Intrinsic Brain Network Biomarkers of Antidepressant Response: a Review.
Intrinsic Brain Network Biomarkers of Antidepressant Response: a Review.
Katharine Dunlop, Aleksandr Talishinsky, Conor Liston
Current psychiatry reports  ·  13 Aug 2019  ·  pubmed:31410661

2018

Stress response regulation and the hemodynamic response.
Stress response regulation and the hemodynamic response.
Katharine Dunlop, Conor Liston
Proceedings of the National Academy of Sciences of the United States of America  ·  11 Oct 2018  ·  pubmed:30309958
Corticostriatal Connectivity in Antisocial Personality Disorder by MAO-A Genotype and Its Relationship to Aggressive Behavior.
Corticostriatal Connectivity in Antisocial Personality Disorder by MAO-A Genotype and Its Relationship to Aggressive Behavior.
Nathan J Kolla, Katharine Dunlop, Jeffrey H Meyer, Jonathan Downar
The international journal of neuropsychopharmacology  ·  01 Aug 2018  ·  pubmed:29746646

2017

Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.
Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.
Peter W Fettes, Massieh Moayedi, Katharine Dunlop, Farrokh Mansouri, Fidel Vila-Rodriguez, …, Raymond W Lam, Sidney H Kennedy, Zafiris J Daskalakis, Daniel M Blumberger, Jonathan Downar
Biological psychiatry. Cognitive neuroscience and neuroimaging  ·  27 Dec 2017  ·  pubmed:29628066
Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open-label case series.
Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open-label case series.
D Blake Woodside, Patricia Colton, Eileen Lam, Katharine Dunlop, Julia Rzeszutek, Jonathan Downar
The International journal of eating disorders  ·  16 Aug 2017  ·  pubmed:28815666
A Fast EEG Forecasting Algorithm for Phase-Locked Transcranial Electrical Stimulation of the Human Brain.
A Fast EEG Forecasting Algorithm for Phase-Locked Transcranial Electrical Stimulation of the Human Brain.
Farrokh Mansouri, Katharine Dunlop, Peter Giacobbe, Jonathan Downar, José Zariffa
Frontiers in neuroscience  ·  20 Jul 2017  ·  pubmed:28775678
Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation.
Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation.
Anuj Rastogi, Robin Cash, Katharine Dunlop, Michael Vesia, Aaron Kucyi, Ayda Ghahremani, Jonathan Downar, Joyce Chen, Robert Chen
NeuroImage  ·  29 Jun 2017  ·  pubmed:28669908
Ensuring that novel resting-state fMRI metrics are physiologically grounded, interpretable and meaningful A commentary on Canna et al., 2017 .
Ensuring that novel resting-state fMRI metrics are physiologically grounded, interpretable and meaningful (A commentary on Canna et al., 2017).
Katharine Dunlop, Jonathan Downar
The European journal of neuroscience  ·  28 Mar 2017  ·  pubmed:28267225
Erratum: Resting-state connectivity biomarkers define neurophysiological subtypes of depression.
Erratum: Resting-state connectivity biomarkers define neurophysiological subtypes of depression.
Andrew T Drysdale, Logan Grosenick, Jonathan Downar, Katharine Dunlop, Farrokh Mansouri, …, Alvaro Pascual-Leone, Henning U Voss, B J Casey, Marc J Dubin, Conor Liston
Nature medicine  ·  07 Feb 2017  ·  pubmed:28170383

2016

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment.
Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment.
Sarah K Peters, Katharine Dunlop, Jonathan Downar
Frontiers in systems neuroscience  ·  27 Dec 2016  ·  pubmed:28082874
Resting-state connectivity biomarkers define neurophysiological subtypes of depression.
Resting-state connectivity biomarkers define neurophysiological subtypes of depression.
Andrew T Drysdale, Logan Grosenick, Jonathan Downar, Katharine Dunlop, Farrokh Mansouri, …, Alvaro Pascual-Leone, Henning U Voss, B J Casey, Marc J Dubin, Conor Liston
Nature medicine  ·  05 Dec 2016  ·  pubmed:27918562
Brainhack: a collaborative workshop for the open neuroscience community.
Brainhack: a collaborative workshop for the open neuroscience community.
R Cameron Craddock, Daniel S Margulies, Pierre Bellec, B Nolan Nichols, Sarael Alcauter, …, Lucina Q Uddin, John D Van Horn, John W Van Meter, Robert C Welsh, Ting Xu
GigaScience  ·  31 Mar 2016  ·  pubmed:27042293
Targeting Neural Endophenotypes of Eating Disorders with Non-invasive Brain Stimulation.
Targeting Neural Endophenotypes of Eating Disorders with Non-invasive Brain Stimulation.
Katharine A Dunlop, Blake Woodside, Jonathan Downar
Frontiers in neuroscience  ·  16 Feb 2016  ·  pubmed:26909013
Noninvasive brain stimulation treatments for addiction and major depression.
Noninvasive brain stimulation treatments for addiction and major depression.
Katharine Dunlop, Colleen A Hanlon, Jonathan Downar
Annals of the New York Academy of Sciences  ·  05 Feb 2016  ·  pubmed:26849183

2015

Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study.
Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study.
Nathan J Kolla, Katharine Dunlop, Jonathan Downar, Paul Links, R Michael Bagby, Alan A Wilson, Sylvain Houle, Fawn Rasquinha, Alexander I Simpson, Jeffrey H Meyer
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology  ·  21 Dec 2015  ·  pubmed:26908392
Reductions in Cortico-Striatal Hyperconnectivity Accompany Successful Treatment of Obsessive-Compulsive Disorder with Dorsomedial Prefrontal rTMS.
Reductions in Cortico-Striatal Hyperconnectivity Accompany Successful Treatment of Obsessive-Compulsive Disorder with Dorsomedial Prefrontal rTMS.
Katharine Dunlop, Blake Woodside, Marion Olmsted, Patricia Colton, Peter Giacobbe, Jonathan Downar
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  ·  06 Oct 2015  ·  pubmed:26440813
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder.
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder.
Katharine Dunlop, Pauline Gaprielian, Daniel Blumberger, Zafiris J Daskalakis, Sidney H Kennedy, Peter Giacobbe, Jonathan Downar
Journal of visualized experiments : JoVE  ·  11 Aug 2015  ·  pubmed:26327307
Increases in frontostriatal connectivity are associated with response to dorsomedial repetitive transcranial magnetic stimulation in refractory binge purge behaviors.
Increases in frontostriatal connectivity are associated with response to dorsomedial repetitive transcranial magnetic stimulation in refractory binge/purge behaviors.
Katharine Dunlop, Blake Woodside, Eileen Lam, Marion Olmsted, Patricia Colton, Peter Giacobbe, Jonathan Downar
NeuroImage. Clinical  ·  02 Jul 2015  ·  pubmed:26199873

2014

Connectivity-based parcellation of the human frontal polar cortex.
Connectivity-based parcellation of the human frontal polar cortex.
Massieh Moayedi, Tim V Salomons, Katharine A M Dunlop, Jonathan Downar, Karen D Davis
Brain structure & function  ·  14 Jun 2014  ·  pubmed:24927720
The putative impact of metabolic health on default mode network activity and functional connectivity in neuropsychiatric disorders.
The putative impact of metabolic health on default mode network activity and functional connectivity in neuropsychiatric disorders.
Danielle S Cha, Francesco De Michele, Joanna K Soczynska, Hanna O Woldeyohannes, Oksana Kaidanovich-Beilin, …, Anusha Baskaran, Andrea Fagiolini, Roman Reznikov, Paul A Kudlow, Roger S McIntyre
CNS & neurological disorders drug targets  ·  01 Jan 2014  ·  pubmed:25470392

2013

Anhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression.
Anhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression.
Jonathan Downar, Joseph Geraci, Tim V Salomons, Katharine Dunlop, Sarah Wheeler, …, Daniel M Blumberger, Zafiris J Daskalakis, Sidney H Kennedy, Alastair J Flint, Peter Giacobbe
Biological psychiatry  ·  28 Nov 2013  ·  pubmed:24388670
Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder.
Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder.
Tim V Salomons, Katharine Dunlop, Sidney H Kennedy, Alastair Flint, Joseph Geraci, Peter Giacobbe, Jonathan Downar
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  ·  13 Sep 2013  ·  pubmed:24150516